Please provide your email address to receive an email when new articles are posted on . Until the last decade, efforts to develop a therapy that successfully targeted the KRAS mutation had been futile ...

The FDA has put out new draft guidance for cancer drug dose optimization, continuing its move away from the ‘maximum tolerated dose’ (MTD) approach to cancer drug development. With the rise of ...

The medical community today faces a deceptively simple question: How quickly should we act when a child’s life is on the line? I’m a pediatric oncologist, so my answer won’t surprise you — I think we ...

Patritumab Deruxtecan (HER3-DXd; MK-1022) in Non–Small Cell Lung Cancer After Platinum-Based Chemotherapy and Immunotherapy Many drugs in development continue to follow the historical drug development ...

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I ...

Computed tomography (CT) radiation dose optimization encompasses a suite of advanced methodologies designed to minimise patient exposure to ionising radiation while preserving or enhancing diagnostic ...

(Patients with disseminated metastatic disease from breast cancer are likely to have liver involvement in >50% of cases at some point during disease progression.) Zetagen identifies two concentrations ...

Given the advances being made in cancer treatments, it’s time to move beyond the maximum tolerated dose (MTD) to dose-optimization trials for targeted therapies, the U.S. FDA said in a new draft ...

Plus Therapeutics, Inc. has begun treating patients in its ReSPECT-LM dose optimization trial for REYOBIQ (rhenium Re186 obisbemeda), targeting leptomeningeal metastases (LM), a severe complication of ...

The dosage of superplasticizer (SP) plays a vital role in influencing the behaviour of fresh concrete through cementitious paste. For optimizing the SP dosage, generally empirical tests like ...